Sporn, Michael B.

The Retinoids. - Burlington : Elsevier Science, 2012. - 1 online resource (441 p.) - eBooks on Demand .

Front Cover; The Retinoids; Copyright Page; Table of Contents; Contributors; Preface; Contents of Volume 2; Chapter 1. Introduction; I. Historical Background; II. Nomenclature; III. Goal of This Treatise; References; Chapter 2. Chemistry and Physical Properties of Retinoids; I. Introduction; II. Physical Properties; III. Chemical Properties: Reactions of Retinoids; IV. Photochemistry of Retinoids; V. Naturally Occurring Retinoids; VI. Synthetic Retinoids; VII. Retinoidal Benzoic Acid Derivatives; References; Chapter 3. Synthesis of Retinoids Labeled with Radioisotopes; I. Introduction II. Preparation of Labeled Natural Retinoids and DerivativesIII. Preparation of Labeled Synthetic Retinoids; IV. Radiochemical Purity Determination; V. Purification of Labeled Retinoids; VI. Stability, Storage, and Handling of Labeled Retinoids; References; Chapter 4. Extraction, Separation, and Chemical Analysis of Retinoids; I. Introduction; II. Biological Samples; III. Extraction of Retinoids; IV. Reference Standards; V. Separation Methods; VI. Chemical Analysis; References; Chapter 5. Biological Methods of Analysis and Assay of Retinoids- Relationships between Structure and Activity I. Introduction II.In Vivo Methods; III. In Vitro Methods Using Organ Culture; IV. In Vitro Methods Using Cell Culture; V. In Vitro Methods Using Cell-Free Systems; VI. A Critique of the Various Methods for Measurement of Biological Activity of Retinoids; VII. Relationships between Structure and Activity of Retinoids; VIII. Conclusion; References; Chapter 6. Vitamin A in Animal and Human Nutrition; I. Historical Perspective; II. Natural Sources of Vitamin A; III. Vitamin A Value of Diets IV. Determinants of the Dietary Requirements of Laboratory and Domestic Animals and Symptoms of DeficiencyV. Dietary Needs of Humans; VI. Metabolism of Vitamin A; VII. Vitamin A Metabolism in Disease States; VIII. Interaction with Other Micronutrients; IX. Interactions with Gonadal Steroid Hormones; X. Interaction with Adrenocortical Hormones; XI. Vitamin A and Drug Interactions; XII. Vitamin A and Alcohol; XIII. Assessment of Vitamin A Status; XIV. Vitamin A Nutriture and the Public's Health; XV. Epidemiology of Hypovitaminosis A; XVI. Intervention Programs XVII. Treatment of XerophthalamiaXVIII. Hypervitaminosis A; XIX. Public Health Implications of Marginal Hypovitaminosis A; References; Appendix; Index

The Retinoids, Volume 1 covers the chemistry and biology of retinoids, with an emphasis on the role of retinoids in nutrition and in vision. After briefly discussing the discovery and nomenclature of retinoids, this six-chapter volume describes the chemical and physical properties of natural and synthetic retinoids, as well as the retinoidal benzoic acid derivatives. The book goes on describing various reactions with radioisotopes for the synthesis of retinoids and related compounds. Considerable chapters explain the chemical, physical, and biological methodologies for separating and measuring

9780323141611 131.31 (UA)

Physiological effect.
Vitamin A.

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