Big Data Analytics in Genomics. (Record no. 981798)

001 - CONTROL NUMBER
control field EBL4723617
006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS
additional material characteristics m d
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr -n---------
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 170519s2016||||||| s|||||||||||eng|d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9783319412795
Terms of availability 129 (NL),129 (1U)
035 ## - SYSTEM CONTROL NUMBER
System control number EBL4723617
035 ## - SYSTEM CONTROL NUMBER
System control number (OCoLC)961271949
040 ## - CATALOGING SOURCE
Original cataloging agency AU-PeEL
Language of cataloging eng
Transcribing agency AU-PeEL
Modifying agency AU-PeEL
050 #4 - LIBRARY OF CONGRESS CALL NUMBER
Classification number QA75.5-76.95
082 00 - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 004
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (OCLC)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) QA75.5-76.95
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Wong, Ka-Chun.
245 10 - TITLE STATEMENT
Title Big Data Analytics in Genomics.
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Place of publication, distribution, etc Cham :
Name of publisher, distributor, etc Springer International Publishing,
Date of publication, distribution, etc 2016.
300 ## - PHYSICAL DESCRIPTION
Extent 1 online resource (426 p.)
490 0# - SERIES STATEMENT
Series statement eBooks on Demand
505 0# - FORMATTED CONTENTS NOTE
Formatted contents note Preface -- Contents -- Part I Statistical Analytics -- Introduction to Statistical Methods for Integrative Data Analysis in Genome-Wide Association Studies -- 1 Introduction -- 2 Heritability Estimation -- 2.1 The Basic Idea of Heritability Estimation from Pedigree Data -- 2.2 Heritability Estimation Based on GWAS -- 3 Integrative Analysis of Multiple GWAS -- 4 Integrative Analysis of GWAS with Functional Information -- 5 Case Study -- 6 Future Directions and Conclusion -- References -- Robust Methods for Expression Quantitative Trait Loci Mapping -- 1 Introduction -- 2 eQTL Mapping
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 2.1 Group-Wise eQTL Mapping and Challenges -- 2.2 Overview of the Developed Algorithms -- 2.3 Chapter Outline -- 3 Group-Wise eQTL Mapping -- 3.1 Introduction -- 3.2 Related Work -- 3.3 The Problem -- 3.4 Detecting Group-Wise Associations -- 3.4.1 SET-eQTL Model -- 3.4.2 Objective Function -- 3.5 Considering Confounding Factors -- 3.6 Incorporating Individual Effect -- 3.6.1 Objective Function -- 3.6.2 Increasing Computational Speed -- Updating σ2 -- Efficiently Inverting the Covariance Matrix -- 3.7 Optimization -- 3.8 Experimental Results -- 3.8.1 Simulation Study -- Shrinkage of C and BA
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note Computational Efficiency Evaluation -- 3.8.2 Yeast eQTL Study -- cis- and trans-Enrichment Analysis -- Reproducibility of trans Regulatory Hotspots Between Studies -- Gene Ontology Enrichment Analysis -- 3.9 Conclusion -- 4 Incorporating Prior Knowledge for Robust eQTL Mapping -- 4.1 Introduction -- 4.2 Background: Linear Regression with Graph Regularizer -- 4.2.1 Lasso and LORS -- 4.2.2 Graph-Regularized Lasso -- 4.3 Graph-Regularized Dual Lasso -- 4.3.1 Optimization: An Alternating Minimization Approach -- 4.3.2 Convergence Analysis -- 4.4 Generalized Graph-Regularized Dual Lasso
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 4.5 Experimental Results -- 4.5.1 Simulation Study -- 4.5.2 Yeast eQTL Study -- 4.5.3 cis and trans Enrichment Analysis -- 4.5.4 Refinement of the Prior Networks -- Hotspots Analysis -- 4.6 Conclusion -- 5 Discussion -- 5.1 Summary -- 5.2 Future Directions -- References -- Causal Inference and Structure Learning of Genotype-Phenotype Networks Using Genetic Variation -- 1 Introduction -- 2 Mendelian Randomization -- 2.1 Randomized Controlled Trial -- 2.2 Randomized Allocation of Allelic Variation in Genes -- 2.3 Genetic Variants as Instrumental Variables
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 2.3.1 Statistical Association with the Exposure -- 2.3.2 Independence with Exposure-Outcome Confounders -- 2.3.3 Exclusion Restriction -- 3 Causal Model -- 3.1 Functional Causal Representation -- 3.2 Graphical Causal Representation -- 4 Properties Relating Functional and Graphical Models -- 4.1 d-Separability -- 4.2 Global Directed Markov Property -- 4.2.1 Local Directed Markov Property in DAGs -- 4.3 Causal Faithfulness -- 4.4 Factorization of Joint Probability Distribution Functions -- 4.4.1 Factorization and Global Markov Property -- 4.5 Linear Entailment and Partial Correlations
505 8# - FORMATTED CONTENTS NOTE
Formatted contents note 5 Equivalent Models
588 ## -
-- Description based upon print version of record.
650 #4 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Big data.
655 #0 - INDEX TERM--GENRE/FORM
Genre/form data or focus term Electronic books.
776 08 - ADDITIONAL PHYSICAL FORM ENTRY
Display text Print version:
Main entry heading Wong, Ka-Chun
Title Big Data Analytics in Genomics
Place, publisher, and date of publication Cham : Springer International Publishing,c2016
International Standard Book Number 9783319412788
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://uttyler.eblib.com/patron/FullRecord.aspx?p=4723617">http://uttyler.eblib.com/patron/FullRecord.aspx?p=4723617</a>
Link text Click here to view this ebook.
901 ## - LOCAL DATA ELEMENT A, LDA (RLIN)
Platform EBL
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Electronic Book
Source of classification or shelving scheme
Holdings
Withdrawn status Lost item Source of classification or shelving scheme Damaged status Not for loan Permanent Location Current Location Shelving location Date acquired Full call number Barcode Date last seen Uniform Resource Identifier Price effective from Koha item type
          UT Tyler Online UT Tyler Online Online 2017-06-01 QA75.5-76.95 EBL4723617 2017-06-01 http://uttyler.eblib.com/patron/FullRecord.aspx?p=4723617 2017-06-01 Electronic Book