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Regulatory mechanisms of striated muscle contraction / edited by Setsuro Ebashi and Iwao Ohtsuki.

Contributor(s): Ebashi, Setsurō, 1922- | Ohtsuki, Iwao.
Material type: TextTextSeries: Springer.Advances in experimental medicine and biology: v. 592.Publisher: Tokyo ; New York : Springer, c2007Description: 1 online resource (xii, 407 p.) : ill. (some col.).ISBN: 9784431384533; 4431384537; 9786610902286; 6610902283; 4431384510 (Cloth); 9784431384519 (Cloth).Subject(s): Muscle contraction -- Congresses | Biological control systems -- CongressesAdditional physical formats: Print version:: Regulatory mechanisms of striated muscle contraction.DDC classification: 573.7/5 LOC classification: QP321 | .R44 2007Online resources: Click here to view this ebook.
Contents:
Historical aspects. Biological actions of calcium / Andrew Fielding Huxley. Professor Ebashi's journey toward the discovery of troponin: a personal recollection / Makoto Endo. Highlights of the history of calcium regulation of striated muscle / John Gergely -- Regulation by troponin and tropomyosin. Troponin: structure, function and dysfunction / Iwao Ohtsuki. From the crystal structure of troponin to the mechanism of calcium regulation of muscle contraction / Yuichiro Maeda, Yasushi Nitanai and Toshio Oda. Ca ion and the troponin switch / Maia V. Vinogradova ... [et al.] Disposition and dynamics: interdomain orientations in troponin / Ryan M.B. Hoffman and Brian D. Sykes. Structural basis for calcium-regulated relaxation of striated muscles at interaction sites of troponin with actin and tropomyosin / Kenji Murakami ... [et al.] Tropomyosin: regulator of actin filaments / Sarah E. Hitchcock-DeGregori, Norma J. Greenfield and Abhishek Singh. Tropomyosin and troponin cooperativity on the thin filament / Sabrina E. Boussouf and Michael A. Geeves. Conformational changes in reconstituted skeletal muscle thin filaments observed by fluorescence spectroscopy / Masao Miki. Calcium structural transition of troponin in the complexes, on the thin filament, and in muscle fibres, as studied by site-directed spin-labelling EPR / Toshiaki Arata ... [et al.] Crystal structures of troponyosin: flexible coiled-coil / Yasushi Nitanai ... [et al.] C. elegans model for studying tropomyosin and troponin regulations of muscle contraction and animal behavior / Hiroaki Kagawa ... [et al.] Structural and functional analysis of troponins from scallop striated and human cardiac muscles / Fumiaki Yumoto and Masaru Tanokura -- Regulation in cardiac muscle and disorders. Cooperativity in the regulation of force and the kinetics of force development in heart and skeletal muscles / Daniel P. Fitzsimons and Richard L. Moss. Heart failure, ischemia/reperfusion injury and cardiac troponin / R. John Solaro and Grace M. Arteaga. Troponin mutations in cardiomyopathies / Jens Mogensen. Molecular pathogenic mechanisms of cardiomyopathies caused by mutations in cardiac troponin T / Sachio Morimoto. Cardiac troponin levels as a preferable biomarker of myocardial cell degradation / Teruhiko Toyo-oka and Hiroyuki Kumagai -- Regulation by myosin. Regulation by myosin: how calcium regulates some myosins, past and present / Andrew G. Szent-Györgyi. Calcium inhibition of physarum myosin as examined by the recombinant heavy mero-myosin / Hozumi Kawamichi ... [et al.] -- Excitation-contraction coupling and disorder. Calcium-induced release of calcium from the sarcoplasmic reticulum / Makoto Endo. Dysregulation of the gain of CICR through ryanodine receptor1 (RYR1): the putative mechanism underlying malignant hyperthermia / Yasuo Ogawa. Ion pumping by calcium ATPase of sarcoplasmic reticulum / Chikashi Toyoshima. Regulation of cell functions by Ca2+ oscillation / Masamitsu Iino -- Molecular mechanisms of muscle contraction. Evidence about the structural behaviour of myosin crossbridges during muscle contraction / Hugh E. Huxley. Structural alterations of thin actin filaments in muscle contraction by synchrotron x-ray fiber diffraction / Katsuzo Wakabayashi ... [et al.] Regulation of muscle contraction by Ca2+ and ADP: focusing on the auto-oscillation (SPOC) / Shin'ichi Ishiwata ... [et al.] Muscle contraction mechanism based on actin filament rotation / Toshio Yanagida. On the walking mechanism of linear molecular motors / Kazuhiko Kinosita, Jr. ... [et al.] Modeling of the F-actin structure / Toshio Oda ... [et al.].
Summary: Troponin is a central subject in biochemical, biophysical, and physiological research. The discovery of this protein by Professor Setsuro Ebashi in 1965 initiated a new era in research into the molecular biology of the regulation of contraction in striated muscle. Troponin is one of the representative functional proteins in living organisms, and its structure and function have been studied extensively. Recently, the crystallographic structure of troponin ternary complex was determined successfully. Mutations in genes of cardiac isoforms of troponin have been shown to cause cardiomyopathies, an.
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"Proceedings of the symposium entitled, 'Regulatory Proteins of Striated Muscle--Structure, Function and Disorder (33rd NIPS Conference), ' held at Okazaki, Japan, October 25-28, 2005"--T.p. verso.

Includes bibliographical references and index.

Historical aspects. Biological actions of calcium / Andrew Fielding Huxley. Professor Ebashi's journey toward the discovery of troponin: a personal recollection / Makoto Endo. Highlights of the history of calcium regulation of striated muscle / John Gergely -- Regulation by troponin and tropomyosin. Troponin: structure, function and dysfunction / Iwao Ohtsuki. From the crystal structure of troponin to the mechanism of calcium regulation of muscle contraction / Yuichiro Maeda, Yasushi Nitanai and Toshio Oda. Ca ion and the troponin switch / Maia V. Vinogradova ... [et al.] Disposition and dynamics: interdomain orientations in troponin / Ryan M.B. Hoffman and Brian D. Sykes. Structural basis for calcium-regulated relaxation of striated muscles at interaction sites of troponin with actin and tropomyosin / Kenji Murakami ... [et al.] Tropomyosin: regulator of actin filaments / Sarah E. Hitchcock-DeGregori, Norma J. Greenfield and Abhishek Singh. Tropomyosin and troponin cooperativity on the thin filament / Sabrina E. Boussouf and Michael A. Geeves. Conformational changes in reconstituted skeletal muscle thin filaments observed by fluorescence spectroscopy / Masao Miki. Calcium structural transition of troponin in the complexes, on the thin filament, and in muscle fibres, as studied by site-directed spin-labelling EPR / Toshiaki Arata ... [et al.] Crystal structures of troponyosin: flexible coiled-coil / Yasushi Nitanai ... [et al.] C. elegans model for studying tropomyosin and troponin regulations of muscle contraction and animal behavior / Hiroaki Kagawa ... [et al.] Structural and functional analysis of troponins from scallop striated and human cardiac muscles / Fumiaki Yumoto and Masaru Tanokura -- Regulation in cardiac muscle and disorders. Cooperativity in the regulation of force and the kinetics of force development in heart and skeletal muscles / Daniel P. Fitzsimons and Richard L. Moss. Heart failure, ischemia/reperfusion injury and cardiac troponin / R. John Solaro and Grace M. Arteaga. Troponin mutations in cardiomyopathies / Jens Mogensen. Molecular pathogenic mechanisms of cardiomyopathies caused by mutations in cardiac troponin T / Sachio Morimoto. Cardiac troponin levels as a preferable biomarker of myocardial cell degradation / Teruhiko Toyo-oka and Hiroyuki Kumagai -- Regulation by myosin. Regulation by myosin: how calcium regulates some myosins, past and present / Andrew G. Szent-Györgyi. Calcium inhibition of physarum myosin as examined by the recombinant heavy mero-myosin / Hozumi Kawamichi ... [et al.] -- Excitation-contraction coupling and disorder. Calcium-induced release of calcium from the sarcoplasmic reticulum / Makoto Endo. Dysregulation of the gain of CICR through ryanodine receptor1 (RYR1): the putative mechanism underlying malignant hyperthermia / Yasuo Ogawa. Ion pumping by calcium ATPase of sarcoplasmic reticulum / Chikashi Toyoshima. Regulation of cell functions by Ca2+ oscillation / Masamitsu Iino -- Molecular mechanisms of muscle contraction. Evidence about the structural behaviour of myosin crossbridges during muscle contraction / Hugh E. Huxley. Structural alterations of thin actin filaments in muscle contraction by synchrotron x-ray fiber diffraction / Katsuzo Wakabayashi ... [et al.] Regulation of muscle contraction by Ca2+ and ADP: focusing on the auto-oscillation (SPOC) / Shin'ichi Ishiwata ... [et al.] Muscle contraction mechanism based on actin filament rotation / Toshio Yanagida. On the walking mechanism of linear molecular motors / Kazuhiko Kinosita, Jr. ... [et al.] Modeling of the F-actin structure / Toshio Oda ... [et al.].

Troponin is a central subject in biochemical, biophysical, and physiological research. The discovery of this protein by Professor Setsuro Ebashi in 1965 initiated a new era in research into the molecular biology of the regulation of contraction in striated muscle. Troponin is one of the representative functional proteins in living organisms, and its structure and function have been studied extensively. Recently, the crystallographic structure of troponin ternary complex was determined successfully. Mutations in genes of cardiac isoforms of troponin have been shown to cause cardiomyopathies, an.

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