Facilitative glucose transporters in articular chondrocytes : expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines / Ali Mobasheri ... [et al.].
Contributor(s): Mobasheri, A. (Ali).Material type: TextSeries: Springer.Advances in anatomy, embryology, and cell biology: 200.Publisher: Berlin : Springer Verlag, 2008Description: 1 online resource (vi, 88 p.) : ill.ISBN: 9783540788997; 3540788999.Subject(s): Glucose | Articular cartilage | Cartilage cells | CytokinesAdditional physical formats: Print version:: Facilitative glucose transporters in articular chondrocytes.LOC classification: QL801 | .E67 vol.200Online resources: Click here to view this ebook.
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Includes bibliographical references (p. 69-84) and index.
Introduction -- Articular cartilage: structure, function and pathophysiology -- Does arthritis have a nutritional aetiology? -- Metabolic dysfunction in arthritis -- Glucose: an essential metabolite and structural precursor for articular cartilage -- Mammalian sugar transporter families: GLUT and SGLT -- Molecular diversity of facilitative glucose transporters in articular chondrocytes -- Regulation of glucose transport by non-steroidal anti-inflammatory drugs (NSAIDs) -- Glucose transporters in the intervertebral disc -- Glucose transporter expression and regulation in embryonic and mesenchymal stem cells -- Concluding remarks.
Articular cartilage is a unique and highly specialized avascular connective tissue in which the availability of oxygen and glucose is significantly lower than synovial fluid and plasma. Glucose is an essential source of energy during embryonic growth and fetal development and is vital for mesenchymal cell differentiation, chondrogenesis and skeletal morphogenesis. Glucose is an important metabolic fuel for differentiated chondrocytes during post-natal development and in adult articular cartilage and is a common structural precursor for the synthesis of extracellular matrix glycosaminoglycans.
Description based on print version record.