Normal view MARC view ISBD view

Therapeutic proteins : strategies to modulate their plasma half-lives / edited by Roland Kontermann.

Contributor(s): Kontermann, Roland, 1961-.
Material type: TextTextSeries: Wiley Online Library.Methods and principles in medicinal chemistry: v. 48.Publisher: Weinheim, Germany : Wiley-Blackwell, c2012Description: 1 online resource (xviii, 354 p.) : ill. (some col.).ISBN: 9783527644827 (electronic bk.); 3527644822 (electronic bk.); 9783527644797 (electronic bk.); 3527644792 (electronic bk.); 9783527644780 (electronic bk.); 3527644784 (electronic bk.); 9783527644803 (electronic bk.); 3527644806 (electronic bk.).Subject(s): Protein drugs -- Design | Proteins -- Therapeutic useAdditional physical formats: Print version:: Therapeutic proteins.Online resources: Click here to view this ebook.
Contents:
Front Matter -- General Information. Half-Life Modulating Strategies : An Introduction / Roland E Kontermann -- Pharmacokinetics and Half-Life of Protein Therapeutics / Bernd Meibohm -- Half-Life Extension through Chemical and Post-Translational Modifications. Half-Life Extension through PEGylation / Simona Jev₍evar, Menci Kunstelj -- Half-Life Extension of Therapeutic Proteins via Genetic Fusion to Recombinant PEG Mimetics / Uli Binder, Arne Skerra -- Half-Life Extension through -Glycosylation / Fuad Fares -- Polysialic Acid and Polysialylation to Modulate Antibody Pharmacokinetics / Antony Constantinou, Chen Chen, Mahendra P Deonarain -- Half-Life Extension through HESylationʼ / Thomas Hey, Helmut Knoller, Peter Vorstheim -- Half-Life Modulation Involving Recycling by the Neonatal Fc Receptor. The Biology of the Neonatal Fc Receptor (FcRn) / Jonghan Kim -- Half-Life Extension by Fusion to the Fc Region / Jalal A Jazayeri, Graeme J Carroll -- Monomeric Fc Fusion Technology: An Approach to Create Long-Lasting Clotting Factors / Jennifer A Dumont, Xiaomei Jin, Robert T Peters, Alvin Luk, Glenn F Pierce, Alan J Bitonti -- The Diverse Roles of FcRn: Implications for Antibody Engineering / E Sally Ward, Raimund J Ober -- Half-Life Extension by Fusion to Recombinant Albumin / Hubert J Metzner, Thomas Weimer, Stefan Schulte -- AlbudAb₉ Technology Platform₆Versatile Albumin Binding Domains for the Development of Therapeutics with Tunable Half-Lives / Christopher Herring, Oliver Schon -- Half-Life Extension by Binding to Albumin through an Albumin Binding Domain / Fredrik Y Frejd -- Half-Life Extension by Binding to Albumin through Small Molecules / Sabrina Trussel, Joerg Scheuermann, Dario Neri -- Half-Life Extension with Pharmaceutical Formulations. Half-Life Extension with Pharmaceutical Formulations: Liposomes / Astrid Hartung, Gerd Bendas -- Half-Life Extension with Pharmaceutical Formulations: Nanoparticles by the Miniemulsion Process / Katharina Landfester, Anna Musyanovych, Volker Mail̃nder -- Index.
Tags from this library: No tags from this library for this title. Log in to add tags.
Item type Current location Call number URL Status Date due Barcode
Electronic Book UT Tyler Online
Online
RS431.P75 T447 (Browse shelf) https://ezproxy.uttyler.edu/login?url=http://onlinelibrary.wiley.com/book/10.1002/9783527644827 Available ocn779616898

Front Matter -- General Information. Half-Life Modulating Strategies : An Introduction / Roland E Kontermann -- Pharmacokinetics and Half-Life of Protein Therapeutics / Bernd Meibohm -- Half-Life Extension through Chemical and Post-Translational Modifications. Half-Life Extension through PEGylation / Simona Jev₍evar, Menci Kunstelj -- Half-Life Extension of Therapeutic Proteins via Genetic Fusion to Recombinant PEG Mimetics / Uli Binder, Arne Skerra -- Half-Life Extension through -Glycosylation / Fuad Fares -- Polysialic Acid and Polysialylation to Modulate Antibody Pharmacokinetics / Antony Constantinou, Chen Chen, Mahendra P Deonarain -- Half-Life Extension through HESylationʼ / Thomas Hey, Helmut Knoller, Peter Vorstheim -- Half-Life Modulation Involving Recycling by the Neonatal Fc Receptor. The Biology of the Neonatal Fc Receptor (FcRn) / Jonghan Kim -- Half-Life Extension by Fusion to the Fc Region / Jalal A Jazayeri, Graeme J Carroll -- Monomeric Fc Fusion Technology: An Approach to Create Long-Lasting Clotting Factors / Jennifer A Dumont, Xiaomei Jin, Robert T Peters, Alvin Luk, Glenn F Pierce, Alan J Bitonti -- The Diverse Roles of FcRn: Implications for Antibody Engineering / E Sally Ward, Raimund J Ober -- Half-Life Extension by Fusion to Recombinant Albumin / Hubert J Metzner, Thomas Weimer, Stefan Schulte -- AlbudAb₉ Technology Platform₆Versatile Albumin Binding Domains for the Development of Therapeutics with Tunable Half-Lives / Christopher Herring, Oliver Schon -- Half-Life Extension by Binding to Albumin through an Albumin Binding Domain / Fredrik Y Frejd -- Half-Life Extension by Binding to Albumin through Small Molecules / Sabrina Trussel, Joerg Scheuermann, Dario Neri -- Half-Life Extension with Pharmaceutical Formulations. Half-Life Extension with Pharmaceutical Formulations: Liposomes / Astrid Hartung, Gerd Bendas -- Half-Life Extension with Pharmaceutical Formulations: Nanoparticles by the Miniemulsion Process / Katharina Landfester, Anna Musyanovych, Volker Mail̃nder -- Index.

Includes bibliographical references and index.

Description based on print version record.

Author notes provided by Syndetics

Roland Kontermann obtained his PhD in Molecular Biology from the University of Heidelberg. After working as a postdoc in the laboratory of Sir Gregory Winter at the MRC Centre for Protein Engineering, Cambridge, UK, he was a group leader at the Institute of Molecular Biology and Tumor Biology of the University of Marburg, and subsequently Head of Research at vectron therapeutics AG. Since 2004 he is Professor of Biomedical Engineering at the Institute of Cell Biology and Immunology of the University of Stuttgart. Current research focuses on the development of recombinant bispecific and bifunctional antibody molecules, including half-life extension strategies, and targeted nanoparticulate carrier systems for tumor therapy. He has over 60 scientific publications and co-editor (together with Stefan Dubel) of the Antibody Engineering Lab Manual.

There are no comments for this item.

Log in to your account to post a comment.