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Molecular Pathogenesis of Colorectal Cancer.

By: Haigis, Kevin M.
Material type: TextTextSeries: eBooks on Demand.Publisher: Dordrecht : Springer, 2013Description: 1 online resource (319 p.).ISBN: 9781461484127.Subject(s): Molecular diagnosis | Pathology, Molecular | Technology, MedicalGenre/Form: Electronic books.Additional physical formats: Print version:: Molecular Pathogenesis of Colorectal CancerDDC classification: 616.075 LOC classification: RC71.3 .H384 2013Online resources: Click here to view this ebook.
Contents:
Preface; Contents; Chapter 1: The Genetics of Colorectal Cancer; 1.1 Introduction; 1.2 Genetic vs. Environmental Components of Colorectal Cancer Risk; 1.3 Early History of Colorectal Cancer Genetics; 1.4 APC and Familial Adenomatous Polyposis; 1.5 MUTYH and Familial Adenomatous Polyposis; 1.6 DNA Mismatch Repair Genes and Lynch Syndrome; 1.7 Additional Candidate Genes in the DNA Mismatch Repair Pathway; 1.8 Dominant Inheritance of Lynch Syndrome; 1.9 Heterogeneity of Lynch Syndrome in Different Families; 1.10 Alternative Lynch Syndrome Inheritance/Familial Colorectal Cancer Type X
1.11 BMPR1A, SMAD4, and Familial Juvenile Polyposis1.12 PTEN and Cowden Syndrome; 1.13 STK11 / LKB1 and Peutz-Jeghers Syndrome; 1.14 Summary and Conclusions; References; Chapter 2: Molecular Mechanisms of Colorectal Carcinogenesis; 2.1 Introduction; 2.2 CIN: Chromosomal Instability Pathway; 2.2.1 The Adenoma-Carcinoma Sequence; 2.2.2 Genomic Instability and Cancer; 2.2.3 Mechanisms Leading to Chromosomal Instability; 2.2.3.1 Defects in Chromosomal Segregation; 2.2.3.2 Centromere Dysfunction; 2.2.3.3 Telomere Dysfunction; 2.2.3.4 Loss of Heterozygosity
2.2.3.5 Deficiencies in DNA Damage Response2.2.4 Genetic Abnormalities Implicated in the Chromosomal Instability Pathway; 2.2.4.1 APC and the Wnt Pathway; 2.2.4.2 Other Mutations in Wnt Pathway Components; 2.2.4.3 KRAS; 2.2.4.4 PIK3CA and PTEN; 2.2.4.5 TP53; 2.2.4.6 Aneuploidy: 18q Loss; 2.2.4.7 TGF-β Type II Receptor; 2.2.4.8 Aneuploidy: Inactivation of CDC4 and Chromosome 1p Deletion; 2.2.4.9 CMYC, CCNE1, and FBW7; 2.2.4.10 CDK8; 2.2.4.11 COX2; 2.2.4.12 LKB1; 2.2.5 Timing of CIN; 2.2.6 Clinical Implications of CIN; 2.3 Microsatellite Instability in Colorectal Cancer; 2.3.1 DNA MMR System
2.3.2 Lynch Syndrome2.3.3 Sporadic MSI; 2.3.4 Epigenetic Changes in CRC and CpG Island Methylator Phenotype; 2.3.5 Pathophysiology of Colorectal Carcinogenesis with MSI; 2.3.6 MSI and Inflammatory Bowel Disease; 2.3.7 Clinical Diagnosis of MSI; 2.3.8 MSI and Response to Chemotherapy; 2.4 The Serrated Pathway in Colorectal Cancer Pathogenesis; 2.4.1 Classification of Serrated Polyps; 2.4.1.1 Hyperplastic Polyp; 2.4.1.2 Sessile Serrated Polyp; 2.4.1.3 Dysplastic Serrated Polyps; 2.4.2 Epidemiology; 2.4.3 Serrated Polyps, MSI, CIMP, and BRAF
2.4.4 Initiation and Progression of the Serrated Pathway2.4.5 An Alternate Serrated Pathway; 2.4.6 Risk Factors for Serrated CRC; 2.4.7 Clinical Characteristics of Serrated CRC; 2.4.8 Detection and Surveillance of Serrated Polyps; 2.4.9 Models of the Serrated Pathway; 2.5 Conclusions; References; Chapter 3: The Association Between Inflammation and Colorectal Cancer; 3.1 The Link Between Inflammation and Cancer; 3.2 The Link Between Inflammation and Colorectal Cancer: Insights from Inflammatory Bowel Disease; 3.2.1 Molecular Mechanisms Underlying Colitis-Associated Cancer Development
3.2.1.1 Inflammation Induces Genetic and Epigenetic Alterations in Epithelial Cells
Summary: Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel
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Electronic Book UT Tyler Online
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RC71.3 .H384 2013 (Browse shelf) http://uttyler.eblib.com/patron/FullRecord.aspx?p=1466357 Available EBL1466357

Preface; Contents; Chapter 1: The Genetics of Colorectal Cancer; 1.1 Introduction; 1.2 Genetic vs. Environmental Components of Colorectal Cancer Risk; 1.3 Early History of Colorectal Cancer Genetics; 1.4 APC and Familial Adenomatous Polyposis; 1.5 MUTYH and Familial Adenomatous Polyposis; 1.6 DNA Mismatch Repair Genes and Lynch Syndrome; 1.7 Additional Candidate Genes in the DNA Mismatch Repair Pathway; 1.8 Dominant Inheritance of Lynch Syndrome; 1.9 Heterogeneity of Lynch Syndrome in Different Families; 1.10 Alternative Lynch Syndrome Inheritance/Familial Colorectal Cancer Type X

1.11 BMPR1A, SMAD4, and Familial Juvenile Polyposis1.12 PTEN and Cowden Syndrome; 1.13 STK11 / LKB1 and Peutz-Jeghers Syndrome; 1.14 Summary and Conclusions; References; Chapter 2: Molecular Mechanisms of Colorectal Carcinogenesis; 2.1 Introduction; 2.2 CIN: Chromosomal Instability Pathway; 2.2.1 The Adenoma-Carcinoma Sequence; 2.2.2 Genomic Instability and Cancer; 2.2.3 Mechanisms Leading to Chromosomal Instability; 2.2.3.1 Defects in Chromosomal Segregation; 2.2.3.2 Centromere Dysfunction; 2.2.3.3 Telomere Dysfunction; 2.2.3.4 Loss of Heterozygosity

2.2.3.5 Deficiencies in DNA Damage Response2.2.4 Genetic Abnormalities Implicated in the Chromosomal Instability Pathway; 2.2.4.1 APC and the Wnt Pathway; 2.2.4.2 Other Mutations in Wnt Pathway Components; 2.2.4.3 KRAS; 2.2.4.4 PIK3CA and PTEN; 2.2.4.5 TP53; 2.2.4.6 Aneuploidy: 18q Loss; 2.2.4.7 TGF-β Type II Receptor; 2.2.4.8 Aneuploidy: Inactivation of CDC4 and Chromosome 1p Deletion; 2.2.4.9 CMYC, CCNE1, and FBW7; 2.2.4.10 CDK8; 2.2.4.11 COX2; 2.2.4.12 LKB1; 2.2.5 Timing of CIN; 2.2.6 Clinical Implications of CIN; 2.3 Microsatellite Instability in Colorectal Cancer; 2.3.1 DNA MMR System

2.3.2 Lynch Syndrome2.3.3 Sporadic MSI; 2.3.4 Epigenetic Changes in CRC and CpG Island Methylator Phenotype; 2.3.5 Pathophysiology of Colorectal Carcinogenesis with MSI; 2.3.6 MSI and Inflammatory Bowel Disease; 2.3.7 Clinical Diagnosis of MSI; 2.3.8 MSI and Response to Chemotherapy; 2.4 The Serrated Pathway in Colorectal Cancer Pathogenesis; 2.4.1 Classification of Serrated Polyps; 2.4.1.1 Hyperplastic Polyp; 2.4.1.2 Sessile Serrated Polyp; 2.4.1.3 Dysplastic Serrated Polyps; 2.4.2 Epidemiology; 2.4.3 Serrated Polyps, MSI, CIMP, and BRAF

2.4.4 Initiation and Progression of the Serrated Pathway2.4.5 An Alternate Serrated Pathway; 2.4.6 Risk Factors for Serrated CRC; 2.4.7 Clinical Characteristics of Serrated CRC; 2.4.8 Detection and Surveillance of Serrated Polyps; 2.4.9 Models of the Serrated Pathway; 2.5 Conclusions; References; Chapter 3: The Association Between Inflammation and Colorectal Cancer; 3.1 The Link Between Inflammation and Cancer; 3.2 The Link Between Inflammation and Colorectal Cancer: Insights from Inflammatory Bowel Disease; 3.2.1 Molecular Mechanisms Underlying Colitis-Associated Cancer Development

3.2.1.1 Inflammation Induces Genetic and Epigenetic Alterations in Epithelial Cells

Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel

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