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Integrative Biology of Women's Health.

By: Spangenburg, Espen E.
Material type: TextTextSeries: eBooks on Demand.Publisher: Dordrecht : Springer, 2013Description: 1 online resource (217 p.).ISBN: 9781461486305.Subject(s): Biology | Developmental biology | Women -- Health and hygieneGenre/Form: Electronic books.Additional physical formats: Print version:: Integrative Biology of Women’s HealthDDC classification: 571.6 Online resources: Click here to view this ebook.
Contents:
Preface; Contents; Contributors; Chapter 1: Influence of Ovarian Hormones on Skeletal Muscle Contractility; Introduction; Estradiol and Muscle Strength; Estradiol and Parameters of Muscle Contractility Other than Strength; Summary; References; Chapter 2: Novel Findings in Bone Biology: Impact on Bone Health for Women; Introduction; Impact of Reduced Dietary Energy Intake on Bone Integrity; Estrogen Receptor-Alpha and Mechanotransduction in Bone; Oxidative Stress: New Mechanism for Aging-Related Bone Loss?; Conclusion; References; Chapter 3: Estrogen Effects on Skeletal Muscle
Estrogen Effects on Muscle MassEstrogen Effects on Muscle Strength; E2 and Exercise Effects; E2 Effects on Muscle May Be Fast Acting or Exerted Through ER; E2 Effects on Gene Expression; Indirect Effects of E2 on Skeletal Muscle; Protective Effects of E2 on Skeletal Muscle Injury; E2 Effects on Simulated Bed Rest; Alternatives to E2; References; Chapter 4: The Contribution of Ovarian Hormones to the Cellular Regulation of Lipid Metabolism; Our Understanding of Metabolic Function in Various Tissues Is Advancing
From a Metabolic Perspective the Differences Between Men and Women Are UnderappreciatedThe Ovary Is Critical for Defining the Metabolic Phenotype of Women; Loss of Ovarian Function Increases the Mortality of Women Independent of Age; Ovariectomy Results in Reduced Physical Activity and Visceral Adiposity; Development of Visceral Adiposity After Ovarian Ablation Leads to Lipolytic Dysfunction in Adipocytes and Fatty Acid Overflow; Skeletal Muscle Is a Primary Storage Depot for Excess Circulating Lipid Under Conditions of Reduced Ovarian Function
Uncovering the Metabolic Mechanisms That Contribute to Increased IMTG Content and Onset of Insulin Resistance in Skeletal Muscle Under Conditions of Ovarian Dysfunction Remain ElusiveEvidence Suggests That Estrogens Are Likely the Key Ovarian Hormone That Influences the Overall Metabolic Phenotype; Disruption of Ovarian Function in Women Is a Broader Health Implication and Deserves More Consideration Than Just Under Conditions of Age-Induced Menopause; Optimal Ovarian Function Is Necessary to Protect the Women from Lipid-Based Insults; References
Chapter 5: The Role of Estrogens in the Regulation of Peripheral Glucose DynamicsGlucose Homeostasis; Clinical Evidence for the Role of Estrogen in Glucose Regulation; Data from Animal Models Support Clinical Findings of Estrogen's Role in Glucose Metabolism; Estrogen Receptors; Mechanisms of ER-Mediated Glucose Metabolism; Estrogen Regulation of Glucose in Insulin-Sensitive Tissues; Estrogen Regulation of Glucose Metabolism in Skeletal Muscle; Estrogen Regulation of Glucose Metabolism in Adipose Tissue; Estrogen Regulation of Glucose Metabolism in the Liver; Conclusion; References
Chapter 6: The Impact of Estrogen Receptor α Expression in the Pathogenesis of the Metabolic Syndrome
Summary: Defining and understanding cellular and molecular mechanisms that are relevant to women’s health has become a critical area of scientific pursuit. Until recently, very little effort has been place on defining or understanding critical differences between women and men that may be critical to the overall health of the woman. In 1990, the National Institutes of Health recognized this gap in knowledge resulting in the creation of the Office of Research on Women’s Health. One of the purposes of this office was to advance the understanding of health issues from the women’s perspective from bo
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Preface; Contents; Contributors; Chapter 1: Influence of Ovarian Hormones on Skeletal Muscle Contractility; Introduction; Estradiol and Muscle Strength; Estradiol and Parameters of Muscle Contractility Other than Strength; Summary; References; Chapter 2: Novel Findings in Bone Biology: Impact on Bone Health for Women; Introduction; Impact of Reduced Dietary Energy Intake on Bone Integrity; Estrogen Receptor-Alpha and Mechanotransduction in Bone; Oxidative Stress: New Mechanism for Aging-Related Bone Loss?; Conclusion; References; Chapter 3: Estrogen Effects on Skeletal Muscle

Estrogen Effects on Muscle MassEstrogen Effects on Muscle Strength; E2 and Exercise Effects; E2 Effects on Muscle May Be Fast Acting or Exerted Through ER; E2 Effects on Gene Expression; Indirect Effects of E2 on Skeletal Muscle; Protective Effects of E2 on Skeletal Muscle Injury; E2 Effects on Simulated Bed Rest; Alternatives to E2; References; Chapter 4: The Contribution of Ovarian Hormones to the Cellular Regulation of Lipid Metabolism; Our Understanding of Metabolic Function in Various Tissues Is Advancing

From a Metabolic Perspective the Differences Between Men and Women Are UnderappreciatedThe Ovary Is Critical for Defining the Metabolic Phenotype of Women; Loss of Ovarian Function Increases the Mortality of Women Independent of Age; Ovariectomy Results in Reduced Physical Activity and Visceral Adiposity; Development of Visceral Adiposity After Ovarian Ablation Leads to Lipolytic Dysfunction in Adipocytes and Fatty Acid Overflow; Skeletal Muscle Is a Primary Storage Depot for Excess Circulating Lipid Under Conditions of Reduced Ovarian Function

Uncovering the Metabolic Mechanisms That Contribute to Increased IMTG Content and Onset of Insulin Resistance in Skeletal Muscle Under Conditions of Ovarian Dysfunction Remain ElusiveEvidence Suggests That Estrogens Are Likely the Key Ovarian Hormone That Influences the Overall Metabolic Phenotype; Disruption of Ovarian Function in Women Is a Broader Health Implication and Deserves More Consideration Than Just Under Conditions of Age-Induced Menopause; Optimal Ovarian Function Is Necessary to Protect the Women from Lipid-Based Insults; References

Chapter 5: The Role of Estrogens in the Regulation of Peripheral Glucose DynamicsGlucose Homeostasis; Clinical Evidence for the Role of Estrogen in Glucose Regulation; Data from Animal Models Support Clinical Findings of Estrogen's Role in Glucose Metabolism; Estrogen Receptors; Mechanisms of ER-Mediated Glucose Metabolism; Estrogen Regulation of Glucose in Insulin-Sensitive Tissues; Estrogen Regulation of Glucose Metabolism in Skeletal Muscle; Estrogen Regulation of Glucose Metabolism in Adipose Tissue; Estrogen Regulation of Glucose Metabolism in the Liver; Conclusion; References

Chapter 6: The Impact of Estrogen Receptor α Expression in the Pathogenesis of the Metabolic Syndrome

Defining and understanding cellular and molecular mechanisms that are relevant to women’s health has become a critical area of scientific pursuit. Until recently, very little effort has been place on defining or understanding critical differences between women and men that may be critical to the overall health of the woman. In 1990, the National Institutes of Health recognized this gap in knowledge resulting in the creation of the Office of Research on Women’s Health. One of the purposes of this office was to advance the understanding of health issues from the women’s perspective from bo

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