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Theories of Population Variation in Genes and Genomes.

By: Christiansen, Freddy Bugge.
Material type: TextTextSeries: eBooks on Demand.Princeton Series in Theoretical and Computational Biology: Publisher: Princeton : Princeton University Press, 2014Description: 1 online resource (432 p.).ISBN: 9781400866656.Subject(s): Ethnicity | Evolutionary genetics | Population genetics -- Textbooks | Population geneticsGenre/Form: Electronic books.Additional physical formats: Print version:: Theories of Population Variation in Genes and GenomesDDC classification: 576.5 | 576.58 Online resources: Click here to view this ebook.
Contents:
""Cover""; ""Title""; ""Copyright""; ""Contents""; ""Preface and Acknowledgments""; ""Introduction""; ""I Genetic Variation ""; ""1 Genetics ""; ""1.1 Genetic Variation""; ""1.1.1 Gene structure and function""; ""1.1.2 Molecular genetic variation""; ""2 Conservation of Variation ""; ""2.1 Stochastic Fluctuations""; ""2.2 Wright�Fisher Process""; ""2.2.1 Multiple alleles""; ""2.3 Gene Identity in a Finite Population""; ""2.4 Coalescence of Genes""; ""2.5 Characteristic Time Unit""; ""2.6 Diffusion Approximation""; ""2.6.1 The Wright�Fisher model""; ""2.6.2 The coalescent""
""2.6.3 The �-coalescent """"2.7 Moran�s Model""; ""3 Diploid Populations ""; ""3.1 Random Mating""; ""3.1.1 Mating of individuals""; ""3.1.2 Random mating and selfing""; ""3.2 Effective Population Size""; ""3.2.1 Lose variation or gain identity""; ""3.2.2 An exponentially growing population""; ""3.2.3 Overlapping generations""; ""3.3 Genotypic Frequencies""; ""4 Mutation and Variation ""; ""4.1 Mutation""; ""4.1.1 Induced mutation""; ""4.1.2 Somatic mutation""; ""4.1.3 Effects of mutations""; ""4.2 The Two-Allele Model""; ""4.2.1 Distribution of the gene frequency""
""4.3 Genealogy and Variation""""4.3.1 Alcohol dehydrogenase in Drosophila""; ""4.4 Mutation and Coalescence""; ""4.4.1 The appearance of a sample""; ""4.4.2 Gene identity and mutation""; ""4.5 The Infinite Alleles Model""; ""4.5.1 Heterozygosity in the infinite alleles model""; ""4.6 The Infinite Sites Model""; ""4.7 Age of an Allele""; ""4.8 Numerical Simulations""; ""5 Migration ""; ""5.1 Population Genetics of Migration""; ""5.1.1 Genealogy in a structured population""; ""5.1.2 The final waiting time""; ""5.2 Population Structure""; ""5.2.1 The simple two-island model""
""5.2.2 Coalescence in a widespread population""""5.2.3 Strong migration""; ""5.2.4 The stepping-stone model""; ""5.3 Genotypic Proportions""; ""5.3.1 Description of population structure""; ""6 Linkage ""; ""6.1 The Karyotype""; ""6.1.1 Sex linkage""; ""6.1.2 Linkage map""; ""6.2 Population Genetics of Linkage""; ""6.3 Linkage Equilibrium""; ""6.3.1 The forward equations""; ""6.3.2 Population mixing""; ""6.3.3 Recurrent mixing and migration""; ""6.3.4 Stochastic effects""; ""6.3.5 Backcrosses""; ""6.4 The Ancestral Recombination Graph""; ""6.4.1 Genealogy and recombination""
""6.4.2 The mechanism of recombination""""6.4.3 Gene conversion""; ""6.4.4 The APOE risk factor in Alzheimer�s disease""; ""6.5 Recombination and Physical Distance""; ""7 Phenotypic Variation ""; ""7.1 Quantitative Inheritance""; ""7.1.1 Conservation of variation""; ""7.1.2 Random genetic drift""; ""7.2 Kin Resemblance""; ""7.2.1 The additive model""; ""7.2.2 Parent�offspring covariance""; ""7.2.3 Covariance between sibs""; ""7.3 Inference on the Genotypic Variance""; ""7.3.1 Comparison of populations""; ""7.3.2 Random genetic drift""; ""7.3.3 Applications of quantitative genetics""
""7.4 Mapping of Quantitative Trait Loci""
Summary: This textbook provides an authoritative introduction to both classical and coalescent approaches to population genetics. Written for graduate students and advanced undergraduates by one of the world's leading authorities in the field, the book focuses on the theoretical background of population genetics, while emphasizing the close interplay between theory and empiricism. Traditional topics such as genetic and phenotypic variation, mutation, migration, and linkage are covered and advanced by contemporary coalescent theory, which describes the genealogy of genes in a population, ultimately con
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""Cover""; ""Title""; ""Copyright""; ""Contents""; ""Preface and Acknowledgments""; ""Introduction""; ""I Genetic Variation ""; ""1 Genetics ""; ""1.1 Genetic Variation""; ""1.1.1 Gene structure and function""; ""1.1.2 Molecular genetic variation""; ""2 Conservation of Variation ""; ""2.1 Stochastic Fluctuations""; ""2.2 Wright�Fisher Process""; ""2.2.1 Multiple alleles""; ""2.3 Gene Identity in a Finite Population""; ""2.4 Coalescence of Genes""; ""2.5 Characteristic Time Unit""; ""2.6 Diffusion Approximation""; ""2.6.1 The Wright�Fisher model""; ""2.6.2 The coalescent""

""2.6.3 The �-coalescent """"2.7 Moran�s Model""; ""3 Diploid Populations ""; ""3.1 Random Mating""; ""3.1.1 Mating of individuals""; ""3.1.2 Random mating and selfing""; ""3.2 Effective Population Size""; ""3.2.1 Lose variation or gain identity""; ""3.2.2 An exponentially growing population""; ""3.2.3 Overlapping generations""; ""3.3 Genotypic Frequencies""; ""4 Mutation and Variation ""; ""4.1 Mutation""; ""4.1.1 Induced mutation""; ""4.1.2 Somatic mutation""; ""4.1.3 Effects of mutations""; ""4.2 The Two-Allele Model""; ""4.2.1 Distribution of the gene frequency""

""4.3 Genealogy and Variation""""4.3.1 Alcohol dehydrogenase in Drosophila""; ""4.4 Mutation and Coalescence""; ""4.4.1 The appearance of a sample""; ""4.4.2 Gene identity and mutation""; ""4.5 The Infinite Alleles Model""; ""4.5.1 Heterozygosity in the infinite alleles model""; ""4.6 The Infinite Sites Model""; ""4.7 Age of an Allele""; ""4.8 Numerical Simulations""; ""5 Migration ""; ""5.1 Population Genetics of Migration""; ""5.1.1 Genealogy in a structured population""; ""5.1.2 The final waiting time""; ""5.2 Population Structure""; ""5.2.1 The simple two-island model""

""5.2.2 Coalescence in a widespread population""""5.2.3 Strong migration""; ""5.2.4 The stepping-stone model""; ""5.3 Genotypic Proportions""; ""5.3.1 Description of population structure""; ""6 Linkage ""; ""6.1 The Karyotype""; ""6.1.1 Sex linkage""; ""6.1.2 Linkage map""; ""6.2 Population Genetics of Linkage""; ""6.3 Linkage Equilibrium""; ""6.3.1 The forward equations""; ""6.3.2 Population mixing""; ""6.3.3 Recurrent mixing and migration""; ""6.3.4 Stochastic effects""; ""6.3.5 Backcrosses""; ""6.4 The Ancestral Recombination Graph""; ""6.4.1 Genealogy and recombination""

""6.4.2 The mechanism of recombination""""6.4.3 Gene conversion""; ""6.4.4 The APOE risk factor in Alzheimer�s disease""; ""6.5 Recombination and Physical Distance""; ""7 Phenotypic Variation ""; ""7.1 Quantitative Inheritance""; ""7.1.1 Conservation of variation""; ""7.1.2 Random genetic drift""; ""7.2 Kin Resemblance""; ""7.2.1 The additive model""; ""7.2.2 Parent�offspring covariance""; ""7.2.3 Covariance between sibs""; ""7.3 Inference on the Genotypic Variance""; ""7.3.1 Comparison of populations""; ""7.3.2 Random genetic drift""; ""7.3.3 Applications of quantitative genetics""

""7.4 Mapping of Quantitative Trait Loci""

This textbook provides an authoritative introduction to both classical and coalescent approaches to population genetics. Written for graduate students and advanced undergraduates by one of the world's leading authorities in the field, the book focuses on the theoretical background of population genetics, while emphasizing the close interplay between theory and empiricism. Traditional topics such as genetic and phenotypic variation, mutation, migration, and linkage are covered and advanced by contemporary coalescent theory, which describes the genealogy of genes in a population, ultimately con

Description based upon print version of record.

Author notes provided by Syndetics

Freddy Bugge Christiansen is professor of population biology at the University of Aarhus in Denmark. He is the author of Population Genetics of Multiple Loci and coauthor of Theories of Populations in Biological Communities and Population Genetics .

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