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Precision Molecular Pathology of Breast Cancer.

By: Khan, Ashraf.
Contributor(s): Ellis, Ian O | Hanby, Andrew M | Cosar, Ediz F | Rakha, Emad A | Kandil, Dina.
Material type: TextTextSeries: eBooks on Demand.Molecular Pathology Library: Publisher: New York, NY : Springer New York, 2015Description: 1 online resource (336 p.).ISBN: 9781493928866.Subject(s): Breast -- Cancer -- Pathophysiology | Cancer -- Molecular aspects | Pathology, Cellular | Pathology, MolecularGenre/Form: Electronic books.Additional physical formats: Print version:: Precision Molecular Pathology of Breast CancerDDC classification: 610 Online resources: Click here to view this ebook.
Contents:
Preface; Contents; Contributors; 1 Molecular Basis of Breast Cancer Imaging ; Introduction; Breast-Specific Gamma Imaging (BSGI); Indications; Technique; Advantages; Limitations; Positron Emission Mammography (PEM); Limitations; Advantages; Radiation Risks; Optical Imaging with Near Infrared Spectroscopy; Optical Imaging with Confocal Microscopy; Terahertz Imaging; References; 2 Familial Breast Cancer and Genetic Predisposition in Breast Cancer ; Introduction; Genetics of Breast Cancer; High-Penetrance Genes; Breast Cancer 1, Early Onset (BRCA1); Breast Cancer 2, Early Onset (BRCA2)
Tumor Protein P53 (TP53)Moderate Penetrance Genes; Ataxia Telangiectasia Mutated Gene (ATM); CHEK2 (Checkpoint Kinase 2 Gene); BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1); Partner and Localizer of BRCA2 Gene (PALB2); Other Genetic Mutations Conferring an Increased Risk of Developing Breast Cancer; Genetic Testing and Management of Familial Breast Cancer in the United States; Guidelines for Genetic Testing in the United States; Modality of BRCA Testing; Prevention Strategies and Clinical Management of Familial Breast Cancer; Key Points; References
3 Modelling the Molecular Pathology of Breast Cancer Initiation Introduction; Two-Dimensional (2D) Cell Line Models; Types and Techniques; Suitability of 2D Cultures to Model Breast Cancer Initiation; Three-Dimensional (3D) Models; Types and Techniques; Suitability of 3D Cultures to Model Breast Cancer Initiation; Conclusion; Key Points; References; 4 Molecular Pathology of Precancerous Lesions of the Breast ; Introduction; Low-Grade Precursor Lesions; Salient Histopathological Features; Molecular Features; Phenotypic Characteristics; High Grade Precursor Lesions
Salient Histopathological FeaturesMolecular Features; Phenotypic Features; Other Molecular Characteristics; Clinical Implications of the Molecular Characteristics of DCIS; Conclusion; Key Points; References; 5 Breast Cancer Stem Cells: Role in Tumor Initiation, Progression, and Targeted Therapy ; Introduction; Cancer Stem Cells (CSCs); Approaches Used to Enrich for Breast CSCs; Mammosphere Assay; Side Population Discrimination; Aldeflour Assay; Surface Markers; Hypoxia; Origin of Breast CSCs; Breast CSCs and Tumor Sub-Types; Clinical Importance of Breast CSCs; Conclusions; References
6 Molecular Pathology of Pre-Invasive Ductal Carcinoma Introduction; Diagnosis, Classification, and Prognosis of DCIS; Diagnosis; Classification; Prognosis; Tumorigenesis of DCIS; Chromosomal Aberrations of Low-and High-Grade DCIS; Immunophenotype of Low-and High-Grade DCIS; Molecular Subtyping of DCIS; Molecular Features of DCIS Versus IDC; Future of Molecular Testing in DCIS; Key Points; References; 7 Molecular Pathology of Lobular Carcinoma ; Background; Histological Subtypes; Role of E-Cadherin in Lobular Carcinoma; Classification of Lobular Neoplasia Using Transcriptional Profiling
Chromosomal Abnormalities
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Preface; Contents; Contributors; 1 Molecular Basis of Breast Cancer Imaging ; Introduction; Breast-Specific Gamma Imaging (BSGI); Indications; Technique; Advantages; Limitations; Positron Emission Mammography (PEM); Limitations; Advantages; Radiation Risks; Optical Imaging with Near Infrared Spectroscopy; Optical Imaging with Confocal Microscopy; Terahertz Imaging; References; 2 Familial Breast Cancer and Genetic Predisposition in Breast Cancer ; Introduction; Genetics of Breast Cancer; High-Penetrance Genes; Breast Cancer 1, Early Onset (BRCA1); Breast Cancer 2, Early Onset (BRCA2)

Tumor Protein P53 (TP53)Moderate Penetrance Genes; Ataxia Telangiectasia Mutated Gene (ATM); CHEK2 (Checkpoint Kinase 2 Gene); BRCA1 Interacting Protein C-Terminal Helicase 1 (BRIP1); Partner and Localizer of BRCA2 Gene (PALB2); Other Genetic Mutations Conferring an Increased Risk of Developing Breast Cancer; Genetic Testing and Management of Familial Breast Cancer in the United States; Guidelines for Genetic Testing in the United States; Modality of BRCA Testing; Prevention Strategies and Clinical Management of Familial Breast Cancer; Key Points; References

3 Modelling the Molecular Pathology of Breast Cancer Initiation Introduction; Two-Dimensional (2D) Cell Line Models; Types and Techniques; Suitability of 2D Cultures to Model Breast Cancer Initiation; Three-Dimensional (3D) Models; Types and Techniques; Suitability of 3D Cultures to Model Breast Cancer Initiation; Conclusion; Key Points; References; 4 Molecular Pathology of Precancerous Lesions of the Breast ; Introduction; Low-Grade Precursor Lesions; Salient Histopathological Features; Molecular Features; Phenotypic Characteristics; High Grade Precursor Lesions

Salient Histopathological FeaturesMolecular Features; Phenotypic Features; Other Molecular Characteristics; Clinical Implications of the Molecular Characteristics of DCIS; Conclusion; Key Points; References; 5 Breast Cancer Stem Cells: Role in Tumor Initiation, Progression, and Targeted Therapy ; Introduction; Cancer Stem Cells (CSCs); Approaches Used to Enrich for Breast CSCs; Mammosphere Assay; Side Population Discrimination; Aldeflour Assay; Surface Markers; Hypoxia; Origin of Breast CSCs; Breast CSCs and Tumor Sub-Types; Clinical Importance of Breast CSCs; Conclusions; References

6 Molecular Pathology of Pre-Invasive Ductal Carcinoma Introduction; Diagnosis, Classification, and Prognosis of DCIS; Diagnosis; Classification; Prognosis; Tumorigenesis of DCIS; Chromosomal Aberrations of Low-and High-Grade DCIS; Immunophenotype of Low-and High-Grade DCIS; Molecular Subtyping of DCIS; Molecular Features of DCIS Versus IDC; Future of Molecular Testing in DCIS; Key Points; References; 7 Molecular Pathology of Lobular Carcinoma ; Background; Histological Subtypes; Role of E-Cadherin in Lobular Carcinoma; Classification of Lobular Neoplasia Using Transcriptional Profiling

Chromosomal Abnormalities

Description based upon print version of record.

Author notes provided by Syndetics

<p>Ashraf Khan, MD, FRCPath<br> University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA</p> <p>Ian O. Ellis, MD, FRCPath<br> University of Nottingham, Department of Histopathology, Nottingham City Hospital, Nottingham, UK</p> <p>Andrew M. Hanby, BM, FRCPath<br> St. James University Hospital/University of Leeds, Leeds Institute of Cancer and Pathology, Leeds, West Yorkshire, UK</p> <p>Ediz F. Cosar, MD<br> UMassMemorial Medical Center, University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA</p> <p>Emad Rakha, MD, PhD, FRCPath<br> University of Nottingham, Department of Histopathology, Nottingham City Hospital, Nottingham, UK</p> <p>Dina Kandil, MD<br> UMassMemorial Medical Center, University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA</p>

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